BIBLIOGRAFIJA

 

A. Ukupan broj radova: 50

Broj radova u kojima je kandidat prvi autor:     13

zadnji autor: 12

 

B. Broj znanstvenih radova: 50

Broj radova u kojima je kandidat prvi autor:     13

zadnji autor: 12

 

C. Broj znanstvenih radova u međunarodno važećim časopisima (indeksirani u CC/SCI): 46

Broj radova u kojima je kandidat prvi autor:     11

zadnji autor: 11

 

10 najboljih radova:

  1. Grgurevic L, Macek B, Erjavec I, Oppermann H, Mann M, Vukicevic S. Urine release of systemically administered bone morphogenetic protein hvbrid molecule. Journal ofNephrology 20:311-319,2007. (Cit. 8) (IF 1.138)
  2. Grgurevic L, Macek B, Durdevic D, Vukicevic S. Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrornetry. International Orthopaedics 31:743-751, 2007. (Cit. 16) (IF 0.903)
  3. Andriopoulos Jr B, Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, Knutson MD, Pietrangelo A, Vukicevic S, Lin HY, Babitt JL. BMP-6 is a Key Endogenous Regulator of Hepcidin Expression and Iron Metabolism. Nature Genetics 41:482-487, 2009. (Cit. 382) (IF 34.284)
  4. Vukicevic S, Grgurevic L. BMP-6 and mesenchymal stem ćeli differentiation. Cytokine and Growth Factor Reviews 20:441-8, 2009. (Cit. 66) (IF 6.489)
  5. Grgurevic L, Macek B, Healy DR, Brault AL, Erjavec I, Cipcic A, Grgurevic I, Rogic D, Galesic K, Brkljacic J, Stern-Padovan R, Paralkar VM, Vukicevic S. Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis. Journal of the American Society ofNephrology 22:681-9, 2011. (Cit. 28) (IF 9.663)
  6. Grgurevic L, Macek B, Mercep M, Jelic M, Smoljanovic T, Erjavec I, Dumic-Cule I, Prgomet S, Durdevic D, Vnuk D, Lipar M, Stejskal M, Kufner V, Brkljacic J, Maticic D, Vukicevic S. Bone morphogenetic protein (BMP) l-3 enhances bone repair. Biochemical and Biophysical Research Communications 408:25-31, 2011. (Cit 35) (IF 2.484)
  7. Grazio S, Razdorov G, Erjavec I, Grubisic F, Kusic Z, Punda M, Anticevic D, Vukicevic S, Grgurevic L. Differential expression of proteins with heparin affmity in patients with rheumatoid and psoriatic arthritis- a preliminary study. Clinical and Experimental Rheumatology 31:665-71, 2013. (Cit 6) (IF 2.973)_
  8. 8. Jurisic D, Erjavec I, Trkulja V, Dumic-Cule I, Hadzibegovic I, Kovacevic L, Svagusa T, Stanec Z, Vukicevic S, Grgurevic L. Soluble type III TGFp receptor in diagnosis and follow-up of patients with breast cancer. Growth Factors 20:1-10, 2015. (Cit 2)
  9. Grgurevic L, Christensen GL, Schulz TJ, Vukicevic S. Bone morphogenetic proteins in inflammation, glucose homeostasis and adipose tissue energy metabolism. Cytokine and Growth Factor Reviews 27:105-1810, 2016. (Cit 6) (IF 5.357)
  10. Grgurevic L, Erjavec I, Dumic-Cule I, Bordukalo-Niksic T, Pauk M, Trkulja V, Maticic D, Pecin M, Lipar M, Peric M, Vukicevic V. Osteogrow: A novel bone graft substitute for orthopedic reconstruction. In: Vukicevic S, Sampath TK (editors). Bone Morphogenetic Proteins: Systems Biology Regulators. PIR Series, Springer InternationalPublishing pp. 215-228, 2017.

 

10 najboljih časopisa ("impact factor") u kojima su radovi objavljeni:

  1. Nature Genetics 2009 (IF 34.284)
  2. Blood2011(IF9.898)
  3. Journal of the American Society of Nephrology 2011 (IF 9.663)
  4. Cytokine and Growth Factor Reviews 2009 (IF 6,489)
  5. Journal of Biological Chemistry 2006 (IF 5.808)
  6. Cvtokine and Growth Factor Reviews 2016 (IF 5.357)
  7. Journal of Biological Chemistry 2010 (IF 5.328)
  8. Kidney International 2004 (IF 4.773)
  9. Bone 2015 (IF 4.461)
  10. PlosONE2016 (IF3.234)

 

 Broj citata u SCI:                   

Web of Knowledge:   1002 (h-indeks 13)

Google Scholar:         1508 (h-indeks 16)

Scopus:                        980 (h-indeks 14)

 

Mono autorske knjige:   0
Multiautorske knjige: 7

1.      Borovecki F, Simic P, Grgurevic L, Vukicevic S. BMPs in regeneration of kidney. In: Bone Morphogenetic Proteins: Regeneration of Bone and Bevond (Editors: Vukicevic S, Sampath TK), PIR Series, Birkauser VerlagAG, Basel, Boston, Berlin, pp 213-244, 2004.

2.      Vukicevic S, Simic P, Grgurevic L, Borovecki F, Sampath K. Systemic administration of bone morphogenetic proteins. In: Bone Morphogenetic Proteins: From Local to Systemic Therapeutics (Editors: Vukicevic S, Sampath TK), PIR Series, Birkauser Verlag AG, Basel, Boston, Berlin, pp 317-337, 2008.

3. Vukicevic S, Grgurevic L. Bone morphogenetic proteins in inflammation. In: Encyclopedia of Inflammatory Diseases, Springer Verlag, 2014.

4.      Jelic M, Grgurevic L, Vukicevic S. Scaffold-free Endogenous Healing of the Articular Cartilage Lesion. In: Sports Injuries, Springer Verlag, 2014.

5.      Grgurevic L, Erjavec I, Dumic-Cule I, Bordukalo-Niksic T, Pauk M, Trkulja V, Maticic D, Pecin M, Lipar M, Peric M, Vukicevic S: Osteogrow: A Novel Bone Graft Substitute for Orthopedic. In: Bone Morphogenetic Proteins: System Biology Regulators (Editors: Vukicevic S, Sampath KT), Springer International Publishing AG, 2017.

6.      Sampath KT, Grgurevic L, Vukicevic S: Bone Morphogenetic Protein-7 and Its Role in Acute Kidney Injury and Chronic Kidney Failure. In: Bone Morphogenetic Proteins: System Biology Regulators (Editors: Vukicevic S, Sampath KT), Springer International Publishing AG.2017.

7.      Grgurevic L, Dumic-Cule I, Vukicevic S: BMPs in Inflammation. In: Bone Morphogenetic Proteins: System Biology Regulators (Editors: Vukicevic S, Sampath KT), Springer International Publishing AG, 2017.

 

Uvodna, pozvana predavanja na međunarodnim skupovima:   14

 

Glavni urednik ili član uredništva znanstvenog časopisa:

Recenzent za znanstvene časopise: International Orthopedics, Clinical and Experimental Rheumatology Hindavvi Case Reports in Dentistry, Croatian Medical Journal

 

Broj i kvaliteta učenika: 

Mentorira rad pet pristupnika za izradu doktorske disertacije (Ivana Kovačević Vojtušek, Anamarija Jović, Vojka Zgombić Popović, Lucija Kučko, Vladimir Farkaš). Mentor sedam obranjenih disertacija (Ana Badovinac [2013] „Proteomska analiza epitelnog i vezivnog tkiva paradonta kod pacijenata s agresivnim paradontitisom"; Igor Erjavec [2014] „Utjecaj razine serotonina u plazmi na metabolizam koštane pregradnje"; Ivo Dumic-Cule [2016]

Voditeljstvo domaćih i međunarodnih projekata: 6 projekata

 

Voditeljica projekata:

  1. 2008. "Praćenje uspješnosti cijeljenja prijeloma pomoću novih serumskih markera", sponzor Hrvatski institut za tehnologiju, voditelj projekta dr. se. Lovorka Grgurevic 
  2. 2013. Adris donacije i projekt HEPATOPROTECT i OPREMANJE ZAVODA, voditelj prof.dr.sc. Lovorka Grgurevic
  3. 2013. Projekt potpore sveučilišta REDUSCAR , voditelj prof.dr.sc. Lovorka Grgurevic
  4. 2014. Projekt potpore sveučilišta „Sistemski utjecaj koštanih morfogenetskih proteina 2 i 7 na koštani metabolizam", voditelj prof.dr.sc. Lovorka Grgurevic
  5. 2016. Uspostavni istraživački projekt Hrvatske zaklade za znanost „Novootkrivene cirkulirajuće izoforme BMP l proteina kao biomarkeri i terapijski ciljevi za humane bolesti"
  6. 2017. Donacija Zaklade Adris, projekt „Novi markeri za otkrivanje i praćenje tumora dojke -BIOBREAST"

Nagrade

European Science Foundation (ESF) Travel Award za 8th International Conference on BMPs, Leuven, Belgija, 2010.

European Science Foundation Travel Award (sponzorirano od strane Remedic Network Programme) za sudjelovanje na 8th International Conference on Bone Morphogenetic Proteins. Leuven, Belgija, 2010.

Rad u Journal of the American Society of Nephrology: Grgurevic L, Macek B, Healy DR, Brault AL, Erjavec I, Cipcic A, Grgurevic I, Rogic D, Galesic K, Brkljacic J, Stern-Padovan R, Paralkar VM, Vukicevic S. Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis. J Am Soc Nephrol 22:681-9, 2011. je u istom broju imao editorial-uvodnik: Tolloid-like Proteinases Orchestrate Extracellular Matrix Formation Hirokazu Okada Department of Nephrology, Faculty of Medicine, Saitama Medical, University, Saitama, Japan

Pozvano predavanje "Utilizing osteogenic potential of BMP6 in developing new treatment options. lOth International Conference on Bone Morphogenetic Proteins. 2014, Berlin, Germany. Znanstveni odbor kongresa dodijelio priznanje za inovativni i kreativni doprinos u području koštanih morfogenetskih proteina.

Nagrada Hrvatske akademije znanosti i umjetnosti za najviša znanstvena i umjetnička dostignuća u Republici Hrvatskoj za 2015. godinu za područje medicinskih znanosti za znanstveni doprinos izuzetnog značenja objavljen u znanstvenom radu (Grgurevic L. et al. Journal of American Society ofNephrology 22: 681-692, 2011), ožujak 2016.

Rad u Hormone and Metabolic Research: Dumic-Cule I, Drača N, Tikvica Luetic A, Jezek D, Rogic D, Grgurevic L, Vukicevic S. TSH prevents bone resorption and with calcitriol synergistically stimulates bone formation in rats with low levels of calciotropic hormones. Horm Metab Res 46:305-312, 2014. odabran je za objavu na naslovnoj stranici časopisa.

Pozvano predavanje ,"A BMP6 containing bone grafit substitute" na 7th International Workshop on Advances in the Molecular Pharmacology and Therapeutics of Bone and other Musculoskeletal Diseases, St Catherine's College, Oxford, UK, 2016.

Godišnja nagrade Hrvatske liječničke komore za najzapaženije stručno ostvarenje u 2016. godini.

Priznanje "Neka zvijezde sjaje" devet hrvatskih zastupnika u Europskom parlamentu timu projekta Osteogrovv koji će predstavljati Republiku Hrvatsku u Europskom parlamentu 2018. godine

 

Patenti. 20 izdanih patenata


1.   Vukicevic S, Grgurevic L, Macek B. BMP-1 procollagen C-proteinase for diagnosis and treatment of bone and soft tissue defects and disorders (US 7850964, datum izdavanja 14.12.2010)

2.   Vukicevic S, Grgurevic L. ADAMTS4 as a blood biomarker and therapeutic target for chronic renal failure (EP 2171450, datum izdavanja 21.03.2012)

3.   Grgurevic L, Macek B, Vukicevic S. Blood biomarkers for bone fracture and cartilage injury (US__8182998, datum izdavanja 22.05. 2012) 

4.   Vukicevic S, Grgurevic L, Oppermann H. Whole blood-derived coagulum device for treating bone defects (US 8197840, datum izdavanja 12.06.2012)

5.   Vukicevic S, Grgurevic L, Macek B. BMP-1 procollagen C-proteinase for diagnosis and treatment of bone and soft tissue defects and disorders (JP 5016041, datum izdavanja 15.06.2012)

6.   Vukicevic S, Grgurevic L, Macek B. BMP-1 procollagen C-proteinase for diagnosis and treatment of bone and soft tissue defects and disorders (AU 2007275580, datum izdavanja 12.07.2012)

7.   Vukicevic S, Grgurevic L, Oppermann H. Whole blood-derived coagulum device for treating bone defects (AU 2007275579, datum izdavanja 16.08.2012)

8.   Grgurevic L, Vukicevic S. ADAMTS4 as a blood biomarker and merapeutic target for chronic renal failure (US 8263072, datum izdavanja 11.09.2012)

9.   Vukicevic S, Grgurevic L, Macek B. BMP-1 procollagen C-proteinase for diagnosis and treatment of bone and soft tissue defects and disorders (EP2518496, datum izdavanja.31.10.2012)

10. Vukicevic S, Grgurevic L, Macek S. BMP l procollagen C-proteinase for diagnosis and treatment of bone and soft tissue defects and disorders (ČA 2658582, datum izdavanja 10.12.2013)

11. Vukicevic S, Grgurevic L, Oppermann H. Dispositif a coagulum derive du sang total pour le traitement de defauts osseaux (Whole blood-derived coagulum device for treating bone defects) (ČA 2657819, datum izdavanja 20.05.2014)

12. Vukicevic S, Grgurevic L, Macek B. Methods of preventing ischemia/reperfusion damage to kidney using antibodies that bind BMP-1 isoforms (US 8765127; datum izdavanja 01.07.2014)

13. Vukicevic S, Grgurevic L, Macek B. BMP-1 Procollagen C-Proteinase for Diagnosis and Treatment of Bone and Soft Tissue Defects and Disorders (JP 5616921, datum izdavanja 19.09.2014)

14. Vukicevic S, Grgurevic L, Oppermann H. Whole blood-derived coagulum device for treating bone defects (EP2049040, datum izdavanja 01.04.2015)

15. Vukicevic S, Grgurevic L, Macek B. BMP-1 procollagen C-proteinase for diagnosis and treatment of bone and soft tissue defects and disorders (AU 2012200193, datum izdavanja 23.07.2015)

16. Vukicevic S, Grgurevic L, Oppermann H. Whole blood-derived coagulum device for treating bone defects (Turkish Patent No. 2015/08147, datum izdavanja 01.07.2015)

17. Vukicevic S, Grgurevic L, Macek B. Anti-BMP-1-1 and anti-BMP-1-3 antibodies for use in the treatment of chronic renal failure. (EP 2049893, datum izdavanja 30.11.2016)

18. Vukicevic S, Grgurevic L, Dumic-Cule I. BMP l  Methods and compositions for treating and diagnosing acute mvocardial infarction (JP 6133402, datum izdavanja 24.05.2017)

19. Vukicevic S, Grgurevic L, Macek B. BMP-1 Procollagen C-Proteinase for Diagnosis and Treatment of Bone and Soft Tissue Defects and Disorder (JP 6152154, datum izdavanja 02.07.2017)

20. Vukicevic S, Grgurevic E, Dumic-Cule I. Methods and compositions for treating and diagnosing acute myocardial infarction. (New Zealand Patent No. 631639, datum izdavanja 05.01.2017)

 

Realizacija vlastite zamisli/patenta u proizvodnji: Temeljem 20 izdanih patenata Lovorka Grgurevic je kao inovator dala značaj doprinos u razvoju lijeka za regeneraciju kosti koji je trenutačno u kliničkim ispitivanjima u Austriji i Hrvatskoj, te ima potencijal statusa prvog hrvatskog lijeka za globalnu primjenu koji je osmislila i do kraja razvila akademska zajednica, što je prvi takav primjer uopće. Europska komisija za znanost je nedavno po drugi puta hrvatskoj instituciji - Medicinskom fakultetu u Zagrebu, dodijelila koordinaciju projekta OSTEOproSPINE kojim će se od 2018. testirati novi lijek u bolesnika s boli u stražnjoj slabinskoj kralježnici u četiri kliničke ustanove. Proizvodnja rekombinantnog BMP6 proteina kao biološki aktivne tvari u lijeku Osteogrow odvija se u novoizgrađenim pogonima u Hrvatskoj.

Područje djelovanja: Temeljne medicinske znanosti na katedri za anatomiju Medicinskog fakulteta; voditeljica Centra za proteomiku Medicinskog fakulteta u Zagrebu; predstojnica Zavoda za anatomiju, Sveučilište u Zagrebu, Medicinski fakultet.

Aktivnosti unutar zadnjih 5 godina (radovi, predavanja itd. ) Unutar zadnjih pet godina Lovorka Grgurevic dala je značajan doprinos u otkriću novih molekula koje su potom proizvedene i testiraju se u kliničkim ispitivanjima, objavila je niz zapaženih radova u vodećim svjetskim časopisima i poglavlja u knjigama izdavača Springer International, koordinira uspostavni projekt Hrvatske zaklade za znanost, rukovodi važnim programom Hrvatskog centra izvrsnosti za regenerativnu medicinu, sudjeluje u mnogim sadržajima nastave iz kliničke anatomije, proteomike, postupaka molekularne medicine, te regenerativne medicine u okviru preddiplomskih i poslijediplomskih studija medicine, stomatologije, i drugih fakulteta Sveučilišta u Zagrebu.